Myself; Yourself - Season 1 Episode 11 Confession

Sana visits Asami in the hospital, where Asami reveals that she was the one who sent the anonymous letter claiming that Syuri and Syusuke were in a love hotel. She admits that ever since Syuri rejected her for expressing her feelings towards Syuri, Asami has constantly hated her. When Syuri and Syusuke arrive to visit Asami, she acts normally, although she asks Syuri to converse privately with her. Syuri later runs out of the hospital in tears. The following day, Syuri and Syusuke are absent from school, and Sana realizes that they are running away to avoid being separated. He desperately runs after their train, and reminiscent of Syusuke when Sana left town, Sana yells that they will always be friends, and Syusuke and Syuri erupt in tears.